✅ Product Benefits

1. Relief from chronic constipation — Effective in adults with idiopathic constipation unresponsive to conventional laxatives through enhanced bowel motility.

2. Selective 5-HT₄ receptor agonist — Stimulates gut motility with minimal cardiovascular risk, unlike older prokinetic drugs. 

3. Flexible dosing — Standard adult dose: 2 mg once daily. Start at 1 mg for elderly or severe renal impairment, up to 2 mg if needed. 

4. Low drug interaction risk — Minimal interactions; ketoconazole increases prucalopride level moderately (~40%) but clinically insignificant. No significant effects when co-administered with warfarin, digoxin, paroxetine, or oral contraceptives. 

5. Well-tolerated safety profile — Common mild-to-moderate side effects: headache (~17.8%), abdominal pain, nausea, diarrhea; typically resolve within days. 

6. Convenient administration — A single tablet daily, with or without food—no strict meal timing required. 

7. Dose adjustment in renal/hepatic impairment — For renal impairment (GFR <30 mL/min): 1 mg daily. For severe hepatic impairment (Child‑Pugh C): start at 1 mg, titrate to 2 mg if well tolerated.