💡 Uses & Benefits

• Ideal for bronchial asthma, bronchospasm, and COPD relief

• Helps relax spastic airways in pulmonary conditions with bronchial muscle tightening 

• Safer alternative to Theophylline, thanks to structural modification reducing interaction with A1/A2 adenosine receptors 

• Reduces production of platelet-activating factor and leukotrienes, improving respiratory inflammation control 

📋 Dosage & AdministrationAdults: 200 mg tablet twice or thrice daily; when total daily need is 400 mg, switch to SR form once daily 

• Elderly: 200 mg tablet two or three times daily

• Children (>12 years): 200 mg tablet two or three times daily; in younger children, syrup or weight-based dosing is recommended 

⚠️ Side Effects & Precautions

• Common reactions: nausea, vomiting, headache, insomnia, tachycardia, epigastric discomfort—similar to mild caffeine effects 

• Rare side effects include cardiac arrhythmias or seizures in overdose cases

• Use with caution in elderly, liver impairment, congestive heart failure, severe hypoxemia, or thyroid disorders due to prolonged drug half‑life 

⚕️ Interactions & Contraindications

• Avoid combining with other xanthine derivatives or caffeine-containing foods and beverages to reduce risk of toxicity

• Certain drugs (erythromycin, clindamycin, allopurinol, cimetidine, propranolol, influenza vaccine) may increase Flindof blood levels—dose adjustments may be required

• Phenytoin, smoking, or anticonvulsants may increase metabolism, reducing effectiveness 

• Contraindicated in acute myocardial infarction, hypotension, known hypersensitivity to xanthines, and in lactating women 

👶 Pregnancy & Lactation

• Animal studies show no reproductive harm, but limited human data—prescribe during pregnancy only if benefits outweigh risks

• Contraindicated during lactation due to possible drug transfer in breast milk 

🧃 Overdose

• Overdose may lead to severe cardiac arrhythmias, tonic-clonic seizures, and toxicity signs warranting immediate withdrawal and symptomatic treatment 

🏪 Product Details (Bangladesh)

• Generic: Doxophylline

• Brand: Flindof 200 mg Tablet (Square Pharmaceuticals Ltd.)

• Price: Around ৳6–7.5 per tablet; ~৳60–75 per 10-tablet strip 

  Packaging Options: 10 or 30 tablets per strip/box

• Storage: Keep in a dry, cool place away from light and moisture; store below 30 °C

📋 Quick Summary Table