✅ Use Benefits
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🛡️ Prevents NSAID-Induced Ulcers: Protects the gastric lining in high-risk patients (e.g. elderly, prior ulcer history) during NSAID therapy by promoting mucus and bicarbonate secretion while reducing acid production
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💊 Heals Existing Ulcers: Effective in promoting healing of NSAID-induced or spontaneous gastric and duodenal ulcers when used consistently for 4–8 weeks
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🤰 Labor Induction: Used to induce cervical ripening and uterine contractions via oral or vaginal administration, under close medical supervision
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🩺 Controls Postpartum Hemorrhage (PPH): Can be administered orally (600 mcg) or rectally (up to 1000 mcg) immediately after delivery or in PPH treatment
⚠️ Precautions & Side Effects
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Common GI Issues: Diarrhea (14–40%), abdominal pain (13–20%), nausea, dyspepsia, flatulence, vomiting; risk minimized by taking after meals and avoiding magnesium-containing antacids
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Gynecological Effects: May cause spotting, cramps, menstrual irregularities, or vaginal bleeding in women
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Pregnancy Contraindications: Strictly contraindicated in pregnant women due to abortifacient properties; women of childbearing potential must use effective contraception and confirm negative pregnancy before use
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Other Considerations: Use with caution in elderly, dehydrated, or kidney-impaired patients; monitor blood pressure and avoid during acute fetal distress or placental issues .
📋 Usage & Dosage Overview
| Indication | Dose & Schedule |
|---|---|
| NSAID Ulcer Prophylaxis | 200 mcg 2–4 times daily with meals while on NSAIDs |
| Established Ulcers (NSAID-related) | 800 mcg/day in divided doses for 4–8 weeks |
| Labor Induction | 25–50 mcg oral or vaginal every 4–6 hours up to 200 mcg |
| PPH Prevention | 600 mcg orally immediately after delivery |
| PPH Treatment | 600 mcg orally or 1 g rectally |
ℹ️ Additional Info
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Price in Bangladesh: Approximately ৳40 per tablet (৳401 per 10-tablet strip).
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Manufacturer: Square Pharmaceuticals Ltd., Bangladesh.
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Storage: Store in a cool, dry place away from light; keep out of children’s reach
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