💊 Uses & Benefits

• Menopausal Symptom Relief: Alleviates hot flashes, night sweats, vaginal dryness, and mood disturbances

• Osteoporosis Prevention: Reduces the risk of fractures in postmenopausal women at high risk

• Dual Action: Exhibits estrogenic, progestogenic, and androgenic effects to address multiple menopausal concerns

• Improved Vaginal Health: Enhances vaginal elasticity and reduces atrophy

• Bone Health: Increases bone mineral density, lowering fracture risk

📋 Dosage & Administration

• Dosage: 2.5 mg tablet once daily

• Administration: Swallow whole with water, preferably at the same time each day

• Onset: Symptom improvement typically within a few weeks; optimal results after 3 months

• Starting Treatment:

  • Natural Menopause: Begin at least 12 months after the last natural menstrual period

  • Surgical Menopause: Treatment may commence immediately

• Switching from Other HRT:

  • Sequential HRT: Start the day after completing the previous regimen

  • Continuous Combined HRT: Can start at any time

• Missed Dose: Take as soon as remembered if within 12 hours; otherwise, skip and resume normal schedule

⚠️ Side Effects & Precautions

• Common Side Effects:

  • Vaginal bleeding or spotting (especially in the initial months)

  • Headache, migraine

  • Edema (swelling)

  • Dizziness, nausea, abdominal pain

  • Pruritus (itching), rash

  • Weight gain, mood changes

• Serious Side Effects:

  • Increased risk of stroke, endometrial, and breast cancer

  • Monitor for signs of thromboembolic events

• Contraindications:

  • Pregnancy and lactation

  • Known or suspected hormone-dependent tumors

  • Cardiovascular or cerebrovascular disorders

  • Active deep vein thrombosis or thromboembolic disorders

  • Unexplained vaginal bleeding

  • Severe liver disorders

• Cautions:

  • Use with caution in patients with renal dysfunction, liver disease, epilepsy, migraine, hypercholesterolemia, impaired carbohydrate metabolism, and cholestatic jaundice

💰 Price & Availability

• Manufacturer: Square Pharmaceuticals Ltd.

• Price: Approximately ৳20.13 per tablet; ৳201.30 per strip of 10 tablets

• Availability: Widely available in pharmacies across Bangladesh

🧪 Pharmacology

Renorma contains Tibolone, a synthetic steroid with estrogenic, progestogenic, and androgenic properties. Upon oral administration, Tibolone is metabolized into active metabolites that exert effects on various tissues, including the brain (thermoregulatory centers), bone, and vaginal epithelium, thereby alleviating menopausal symptoms and preventing osteoporosis.